Go straight two blocks. Turn left.

1. It's on your left.
2. It's to your left.
[Can we use 'to' as in #2?]

3. There is a special place for teenagers: Chicago Library.
[Is Chicago Library in apposition with 'a special place for teenagers'?]

4. There is a special place for teenagers, Chicago Library.
[Can we use this way? Is #3 the same as #4? Is 'Chicago Library' in apposition with the previous phrase?]

5. There is a special place for teenagers, that is to say, Chicago Library.
[This one is the same as the previous sentences, isn't it?]

3 answers

"Go straight two blocks, then turn left." would be best if a turn is required. 1 and 2 suggest that the destination is immediately on the left.

Either 3 or 4 can be used, but "that is to say" is unnecessary.

Wouldn't it be "the Chicago Library"?
One and two: yes, we say both.
Three and four: You need the colon, not a comma in this sentence construction. No, "Chicago Library" is not an appositive. An appositive immediately follows the noun it defines. "There is a special place, Chicago Library, for teenagers" is an appositive.
Five means the same as three and four, yes.
PsyDAG is right, in part. If you make the left turn, you will find the destination on the left side of the street (after the turn) is fine, if that's what you mean. If the left turn and the destination are the same, as in turning left into a driveway, these directions could be confusing.
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