The correct response that captures the political and economic changes in medieval Europe leading to European colonization is:
Political changes included the rise of European monarchies and changes in the balance of power in Europe. Economic changes included a rebalance of economic power due to a human labor shortage.
This response accurately reflects the key developments that contributed to the motivations and capacities for European exploration and colonization in the subsequent periods. The rise of monarchies centralized power and resources, while labor shortages following events like the Black Death spurred changes in economic systems and increased the demand for new markets and resources.