The statement that best explains the relationship between the Mexican government and Anglo-American settlers in Texas from 1821 to 1825 is:
Political decisions made by the Mexican government caused a mixture of support and challenge from Anglo-American settlers.
During this period, the Mexican government encouraged settlement in Texas to help develop the region, which initially attracted many Anglo-American settlers. However, as policies and laws began to change, particularly regarding land ownership and immigration, conflicts arose, leading to a complex relationship filled with both cooperation and tension.