The statement that best compares the difference in how the French and the Spanish interacted with Indigenous populations when they arrived in the New World is:
A. the French cultivated an amicable relationship with the indigenous peoples in order to maintain a positive trade relationship. The Spanish enslaved indigenous Americans in order to cultivate the crops that were being traded.
This statement accurately reflects the historical context in which the French often formed trade alliances with Indigenous peoples, whereas the Spanish were more inclined to enslave Indigenous populations for labor in their colonies.