The true statement about cystic fibrosis from the provided options is:
Carriers have an advantage over people who do not have the cystic fibrosis mutation.
This is because individuals who are carriers (heterozygous for the CFTR gene mutation) may have some level of protection against certain illnesses, such as cholera or typhoid fever, which is thought to have provided a selective advantage in certain populations.
The other statements are incorrect:
- Cystic fibrosis is caused by mutations in the CFTR gene, specifically a recessive allele, not a dominant one.
- The most common mutation, ΔF508, is actually a deletion of three nucleotides (which codes for one amino acid), not a deletion of one codon.
- Cystic fibrosis primarily affects the respiratory system and digestive system, not the production of red blood cells.