The effects of Pizarro and Cortés's defeat of Native Americans included:
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Settlement and colonization of Florida under Spanish rule - This was indeed an outcome as Spain expanded its territories in the Americas.
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Inspiration for other Europeans to begin explorations and settlements - The successes of Cortés and Pizarro inspired other European powers and explorers to seek their own conquests and colonization opportunities in the New World.
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Settlements and colonizations in the southwest under Spanish rule - The conquests led to further Spanish exploration and colonization in regions like the Southwestern United States.
The option "fighting between Spanish and the French" is not a direct effect of Cortés and Pizarro's actions. Rather, conflicts between Spain and France occurred later due to broader territorial and colonial disputes in the Americas.
Thus, the relevant effects you should select are the first three options.