The option that likely had the most influence on widespread cultural changes in America is:
Native Americans, Europeans, and African Americans all brought their own unique customs and traditions when these groups came together in America.
This choice recognizes the complex interplay of diverse cultures that shaped American society. The interactions and exchanges among Native Americans, early European settlers, and African Americans created a rich tapestry of cultural practices, beliefs, and traditions that have significantly influenced the development of American culture. Each group's contributions helped mold the social, artistic, and culinary landscape of America, leading to widespread cultural changes.