The evidence that would BEST support the claim that using synthetic fertilizer can be harmful to the environment is:
B. an increase in certain nutrients and algae growth in a lake near a farm field after the application of synthetic fertilizer to the soil
This option indicates a consequence of using synthetic fertilizers, specifically the potential for nutrient runoff that can lead to algal blooms in nearby water bodies. Algal blooms can deplete oxygen in the water, harm aquatic life, and disrupt ecosystems, thereby demonstrating the environmental harm associated with synthetic fertilizer use.