The most accurate response regarding the chain of events that contributed to the Black Death being so deadly is:
Cooling climate led to reduced harvests, which caused people to be ill-nourished and more likely to get sick.
This response reflects the historical context where a series of climate changes known as the Little Ice Age led to poorer harvests in the years leading up to the Black Death, which weakened the population's overall health and resilience against the disease. This malnutrition made individuals more susceptible to the plague once it arrived.