The response that most accurately reflects a chain of events contributing to the deadliness of the Black Death is:
Cooling climate led to reduced harvests, which caused people to be ill-nourished and more likely to get sick.
This option highlights how a drop in agricultural productivity due to climate changes could have weakened the population, making them more susceptible to disease. This exacerbated the impact of the plague when it did arrive, as malnutrition can lead to weakened immune systems.