Use the diagram to answer the question.

Question

Sickle cell anemia

What type of mutation error has occurred to cause the disorder shown?(1 point)
Responses

substitution
substitution

insertion
insertion

frameshift
frameshift

deletion

Answer 1

Sickle cell anemia is caused by a specific type of mutation known as a substitution mutation. In this case, the substitution of one amino acid for another in the hemoglobin protein leads to the misshapen red blood cells characteristic of the disorder. Therefore, the correct response is:

substitution