The number _____ and _____ sign are assigned to the first nucleotide of a transcriptional unit.

a. 0, positive

b. 1, negative

c. 1, positive

d. 0, no sign

No idea what the answer might be.

Since this is not my area of expertise, I searched Google under the key words ""first nucleotide" number sign" to get these possible sources:

http://www.hgvs.org/mutnomen/recs.html
http://www.hgvs.org/mutnomen/recs-DNA.html
(Broken Link Removed)
http://www.chem.qmul.ac.uk/iupac/misc/pnuc1.html

In the future, doing similar searches can help to get your answers more quickly.

I hope this helps. Thanks for asking.