The figure demonstrates significant induction of HbF in certain clones, but there are limitations in interpreting these results. The lack of indel mutations in certain cell lines suggests potential chromatin context interference, and the specific cancer-derived cell lines may not be ideal models for HbF reactivation studies. is this a good limitation
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Yes, this is a valid limitation as it highlights potential confounding factors that may affect the interpretation of the results. It is important to consider the limitations of the experimental model when drawing conclusions from the data.
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