The differences in the economic development of the mid-Atlantic (Middle Colonies), New England, and Southern colonies can BEST be attributed to the geographic conditions there.
Geographic conditions influenced the agricultural outputs, types of trade, and overall economic activities in these regions. For example, the Middle Colonies had fertile soil ideal for grain farming, New England had a more difficult climate for agriculture but thrived in fishing and shipbuilding, and the Southern colonies had warm climates conducive to cash crops like tobacco and rice.