The creature sat upright andtugged at the shackles binding his ankles, frankenstein uttered a piercing scream.
We will be happy to critique your correction to this fused sentence.
Fused sentence, comma splice (which is what this is), or run-on -- they're all the same -- two sentences jammed together, not punctuated correctly.
What are the TWO sentences in here and how will you correct them?
http://grammar.ccc.commnet.edu/grammar/runons.htm
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