Among the options provided, the observation that would most likely indicate that a chemical change has occurred in the substance is:
If the substance is a liquid or solid, production of an odor would indicate a chemical change.
Production of a new odor often signifies that a new substance is being formed, which is a hallmark of a chemical change. The other observations, such as changes in temperature, state (liquid to gas or solid to liquid), can also occur during physical changes or phase transitions and do not necessarily indicate a chemical change on their own.