To solve the equation \(2x - 10x = 72\), start by combining like terms on the left side:
\[ 2x - 10x = -8x \]
So the equation now looks like:
\[ -8x = 72 \]
Next, divide both sides by -8 to isolate \(x\):
\[ x = \frac{72}{-8} \]
Simplifying this gives:
\[ x = -9 \]
Thus, the solution is:
\[ \boxed{-9} \]