Simplify the following:

Question

4pq times -p times 3q times 3q

Answer 1

If your question mean:

4 p ∙ q ∙ ( - p ) ∙ 3 q ∙ 3 q

then
4 ∙ ( - p ) ∙ p ∙ q ∙ 3 q ∙ 3 q =

- 4 p² ∙ 9 q³ = - 36 p² ∙ q³