The best response to the statement about the differences between plant and animal cells is:
a. Plants have a larger vacuole.
Here's why the other options are incorrect:
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b. Only plant cells have rough endoplasmic reticulum: This is incorrect because both plant and animal cells can have rough endoplasmic reticulum; it is involved in protein synthesis in both types of cells.
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c. Animal cells always have cell walls: This is incorrect because animal cells do not have cell walls; they have a flexible plasma membrane.
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d. Plant and animal cells have chloroplasts: This is incorrect because only plant cells (and some protist cells) contain chloroplasts for photosynthesis, while animal cells do not.
So, option (a) correctly states a difference between plant and animal cells regarding the size of the vacuole.