To predict the effect of adding magnesium to the extracellular solution on neurotransmitter release, it is important to understand the role of magnesium in neuronal function.
Magnesium (Mg²⁺) acts as a natural blocker of certain types of ion channels, particularly NMDA receptors and voltage-gated calcium channels. In order for neurotransmitter release to occur, calcium influx into the presynaptic neuron is crucial, as it stimulates the release of neurotransmitters from synaptic vesicles.
If magnesium is added to the extracellular solution, it can inhibit calcium channels and potentially decrease the influx of calcium ions, which would result in less neurotransmitter release.
Therefore, the most likely answer is: • There will be less neurotransmitter release than in the control solution.
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