Based on the historical context of colonial European settlements in North America during the mid-1600s, the most accurate response would be:
D All of the settlements were close to major bodies of water.
This is because colonial settlements were typically established near rivers, lakes, and coastal areas to facilitate trade, transportation, and access to resources. While some settlements may have been along major rivers, it was not exclusively the case that all settlements were along them, and not all settlements actively avoided Indian settlements. Thus, option D is the best summary of the general pattern observed in colonial settlement.