The correct response highlighting the differences in Spanish colonization compared to the French and Dutch efforts is:
Spain created a massive empire.
This reflects the significant and expansive nature of the Spanish Empire, particularly in terms of territorial claims, population, and the integration of indigenous peoples. In contrast, while the French and Dutch also established colonies, their efforts were often more focused on trade (like the fur trade) and had different approaches to indigenous relations and settlement patterns.
The other options are not accurate: Spanish settlements were located across both North and South America, rather than being limited to North America; the Spanish colonization was not primarily a result of the Protestant Reformation; and while the French and Dutch were indeed focused on the fur trade, that was not a major emphasis of Spanish colonization.