The protagonist Natty Bumppo from James Fenimore Cooper's Leatherstocking Tales is primarily associated with the American Frontier. Therefore, the best option that describes the setting of the image would be:
B The Frontier
While other settings like the Iroquois Nation may relate to various aspects of the narrative, the broader context of Natty Bumppo's story aligns most closely with the concept of the frontier, as much of his character and adventures are centered on the interactions between settlers and Native Americans during the westward expansion of the United States.
So, the best choice is B The Frontier.