Based on the context of Natty Bumppo, the protagonist of James Fenimore Cooper's Leatherstocking Tales, the best options that describe the setting of the image would be:
B. The Frontier
D. Iroquois Nation
The Frontier is a prominent theme in Cooper's works, depicting the untamed wilderness and the interactions between settlers and Native Americans. The Iroquois Nation is relevant as it features prominently in the stories involving Natty Bumppo and reflects the historical and cultural context of the time.