The correct response is:
It causes mixing of oxygenated (blood with oxygen in it) and deoxygenated blood (blood without oxygen in it), making it harder for the body to get the oxygen it needs.
In frogs, the heart has one ventricle, which can lead to the mixing of oxygen-rich and oxygen-poor blood, making their circulatory system less efficient than that of mammals, which have a four-chambered heart that separates the two types of blood completely.