The correct response is:
It causes mixing of oxygenated (blood with oxygen in it) and deoxygenated blood (blood without oxygen in it), making it harder for the body to get the oxygen it needs.
Frogs have a three-chambered heart with one ventricle, which allows for the mixing of oxygenated and deoxygenated blood, resulting in less efficient oxygen delivery compared to a system with separate chambers for each type of blood.