Hemoglobin is a protein present in red blood cells. In the genetic disease sickle cell anemia, there is a mutation in the HBB gene that codes for the hemoglobin protein. The mutation results in hemoglobin proteins that clump together abnormally in cells. This leads to red blood cells that are sickled (crescent-shaped) rather than round. Sickled cells are fragile and can cause damage to tissue throughout the body.

Question

How do changes in the HBB gene affect body function? Place phrases into the table in the correct order to explain how changes in the HBB gene affect body tissue function.
Step
1
Sequence of How Changes In HBB Gene Affect Body Tissue Function
2
3
4
Mutation occurs in DNA sequence
Abnormally shaped amino acids form
Mutation occurs during protein folding
Abnormal sequence of amino acids forms
Proteins that form are abnormal in shape and behavior
Cell shape is irregular, resulting in abnormal cell and tissue function

Answer 1

Here is the correct order of the steps explaining how changes in the HBB gene affect body tissue function:

| Step | Sequence of How Changes In HBB Gene Affect Body Tissue Function | |------|------------------------------------------------------------------------------------------------------| | 1 | Mutation occurs in DNA sequence | | 2 | Abnormal sequence of amino acids forms | | 3 | Abnormally shaped amino acids form | | 4 | Mutation occurs during protein folding | | 5 | Proteins that form are abnormal in shape and behavior | | 6 | Cell shape is irregular, resulting in abnormal cell and tissue function |

With these steps, you can see the progression from the genetic mutation to the effect on cell shape and functionality.