The sentence has a slight grammatical error. "Focus" is a singular noun, so it should be paired with a singular verb form. The corrected sentence would be:
"The new focus on values is making an enormous difference for my coworkers and me."
Alternatively, if you were referring to the "focuses" on multiple values, you could say:
"The new focuses on values are making an enormous difference for my coworkers and me."
But this structure is less common. The first correction is likely what you intended.