Can you use TLC to distinguish various isomers from one another? In what kind of substance can you NOT distinguish the isomers from each other?

i think it is not possible to distinguish

If I have an unknown sample containing several ketones and want to use TLC to identify the unknown from a sample of branched hydrocarbons...will my unknown with ketones have more polarity than the branched hydrocarbons rising on the TLC more quickly?

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