Assess with explanation the bioavailability by oral route of the following drugs with the specified properties.
Also suggest ways to achieve the therapeutic concentration if the bioavailability is not favorable.
(Note: change of route of administration should be considered as the last option of resolution)
i. Drug A will be hydrolyzed to 30% of its therapeutic dose in an acidic medium within an hour.
ii. Drug B has a hepatic extraction ratio of 50%.
iii. Drug C is a biopharmaceutical of protein nature.
i i think acidic medium =stomach, so drug interaction can be applied in this case?using some drug to alter the motility rate of gastric emptying?
ii I think the drug is OK because extraction ratio is not too high,but I have no idea to explain in detail
iii it must change the rote of administration because the drug will be digested by gastric acid.
can anyone give me an advice if my answer is valid?
Thank you very much
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