To apply the properties of integer exponents to the expression \( \frac{2^2}{2^{-4}} \), we will use the quotient rule of exponents, which states that:
\[ \frac{a^m}{a^n} = a^{m-n} \]
Applying this to our expression:
\[ \frac{2^2}{2^{-4}} = 2^{2 - (-4)} \]
This simplifies to:
\[ 2^{2 + 4} = 2^6 \]
Now, we need to solve for \( 2^6 \):
\[ 2^6 = 64 \]
So the final answer is:
\[ \frac{2^2}{2^{-4}} = 64 \]