The most accurate analysis of an impact the Columbian Exchange had on the New World is:
D. The spread of diseases decimated the indigenous population of the Americas.
The Columbian Exchange, which began after Columbus's voyages in the late 15th century, facilitated the transfer of crops, animals, and diseases between the Old World (Europe, Asia, and Africa) and the New World (the Americas). One of the most devastating effects of this exchange for the indigenous populations of the Americas was the introduction of European diseases, such as smallpox, influenza, and measles, to which Native Americans had no prior exposure and, therefore, no immunity.
These diseases spread rapidly and led to catastrophic declines in the indigenous populations, with estimates suggesting that up to 90% of some groups may have died due to these illnesses within a few decades of European contact. This significant demographic collapse had profound social, economic, and cultural repercussions for indigenous communities in the New World.