The most accurate response regarding the impact the Columbian Exchange had on the New World is: The spread of diseases decimated the Indigenous population of the Americas.
This statement highlights a significant consequence of the Columbian Exchange, as the introduction of European diseases—such as smallpox, influenza, and measles—had devastating effects on the Indigenous populations who had no immunity to these foreign illnesses. The resulting population decline had profound social, cultural, and economic repercussions for Indigenous communities across the Americas.