The statement that best describes the colonist’s attitude towards Native Americans in the excerpt by John Winthrop is:
They felt their religion was superior and that God had foreordained them to control the land they settled.
This is evident in the way Winthrop refers to the deaths of Native Americans from smallpox as "the Lord hath cleared our title to what we possess," suggesting a belief that their presence was divinely sanctioned and that they had a rightful claim to the land as a result.