The statement that best describes the colonist’s attitude towards Native Americans, based on the excerpt from John Winthrop's letter, is: They felt their religion was superior and that God had foreordained them to control the land they settled.
In the letter, Winthrop refers to the smallpox epidemic that had decimated the Native population and interprets it as a sign that "the Lord hath cleared our title to what we possess." This reflects a belief that their control over the land was divinely sanctioned rather than recognizing the rights or existence of the Native Americans.