Question
What is the major fate of propionyl- CoA produced from odd- chain fatty acids oxidation
Answers
GPT-4o mini
The major fate of propionyl-CoA, produced from the oxidation of odd-chain fatty acids, is its conversion to succinyl-CoA. This conversion occurs through a series of enzymatic reactions, primarily involving the enzyme propionyl-CoA carboxylase, which carboxylates propionyl-CoA to form D-methylmalonyl-CoA. D-methylmalonyl-CoA can then be rearranged to L-methylmalonyl-CoA by the enzyme methylmalonyl-CoA racemase. Finally, L-methylmalonyl-CoA is converted to succinyl-CoA by the enzyme methylmalonyl-CoA mutase, which requires vitamin B12 as a cofactor.
Succinyl-CoA is an important intermediate in the citric acid cycle (Krebs cycle) and can enter various metabolic pathways, including those involved in energy production and the synthesis of certain amino acids.
Succinyl-CoA is an important intermediate in the citric acid cycle (Krebs cycle) and can enter various metabolic pathways, including those involved in energy production and the synthesis of certain amino acids.