Question
Sequences for the types of hemoglobin are shown. A student makes the claim that the sickle-cell hemoglobin sequence is caused by a mutation. The first sequence is normal (wild-type) hemoglobin and the second sequence is the mutated, sickle cell hemoglobin. Sickle-cell
image
Which of the following is evidence to support the claim made by the student?
A.
The sickle-cell hemoglobin sequence is caused by an insertion mutation that occurred during the replication of the DNA.
B.
The sickle-cell hemoglobin sequence is caused by a deletion mutation that occurred during transcription of DNA into mRNA.
C.
The sickle-cell hemoglobin sequence is caused by a substitution mutation that occurred during replication of the DNA.
D.
The sickle-cell hemoglobin sequence is caused by an insertion mutation that occurred during the translation of DNA to mRNA.
image
Which of the following is evidence to support the claim made by the student?
A.
The sickle-cell hemoglobin sequence is caused by an insertion mutation that occurred during the replication of the DNA.
B.
The sickle-cell hemoglobin sequence is caused by a deletion mutation that occurred during transcription of DNA into mRNA.
C.
The sickle-cell hemoglobin sequence is caused by a substitution mutation that occurred during replication of the DNA.
D.
The sickle-cell hemoglobin sequence is caused by an insertion mutation that occurred during the translation of DNA to mRNA.
Answers
GPT-4o mini
The correct answer is:
**C. The sickle-cell hemoglobin sequence is caused by a substitution mutation that occurred during replication of the DNA.**
Sickle-cell disease is a result of a point mutation in the HBB gene that leads to the substitution of valine for glutamic acid at the sixth position of the beta-globin chain of hemoglobin. This mutation occurs during DNA replication, specifically during the synthesis of the gene that codes for hemoglobin. The other options involving insertion or deletion mutations are not accurate descriptions of the mutation causing sickle-cell hemoglobin.
**C. The sickle-cell hemoglobin sequence is caused by a substitution mutation that occurred during replication of the DNA.**
Sickle-cell disease is a result of a point mutation in the HBB gene that leads to the substitution of valine for glutamic acid at the sixth position of the beta-globin chain of hemoglobin. This mutation occurs during DNA replication, specifically during the synthesis of the gene that codes for hemoglobin. The other options involving insertion or deletion mutations are not accurate descriptions of the mutation causing sickle-cell hemoglobin.