The item that does not belong in the group is "England & Ireland" because it refers to locations rather than characters in the play.
Malcolm, Donalbain, and Macduff are all key characters in Shakespeare's "Macbeth". For instance, Malcolm is the legitimate heir to the Scottish throne, as he states, "This murderous shaft that’s shot hath not yet lighted," indicating his role as a leader following Duncan's assassination (Act 3, Scene 2). Donalbain, his brother, also plays a part in the aftermath of Duncan's murder, as they decide to flee to avoid being killed, demonstrating their vulnerability and the impending chaos in Scotland. Macduff, on the other hand, represents a noble character who seeks justice against Macbeth, exclaiming, "O, I could play the woman with mine eyes and braggart with my tongue!" showing his emotional conflict after Duncan's murder and his dedication to avenging it (Act 4, Scene 3). Therefore, the bond among these three characters is tied to their royal lineage and their roles in the power struggle following Duncan's death.