To simplify the expression \( 2^4 \cdot 2^2 \) using the Product Rule of Exponents, you add the exponents when the bases are the same.
The Product Rule states that:
\[ a^m \cdot a^n = a^{m+n} \]
In this case, the base \( a \) is \( 2 \), \( m = 4 \), and \( n = 2 \).
So, we add the exponents:
\[ 2^4 \cdot 2^2 = 2^{4+2} = 2^6 \]
Thus, the simplified expression is:
\[ 2^6 \]