Hemoglobin is a protein present in red blood cells. In the genetic disease sickle cell anemia, there is a mutation in the HBB gene that codes for the hemoglobin protein. The mutation results in hemoglobin proteins that clump together abnormally in cells. This leads to red blood cells that are sickled (crescent-shaped) rather than round. Sickled cells are fragile and can cause damage to tissue throughout the body.

Question

How do changes in the HBB gene affect body function? Place phrases into the table in the correct order to explain how changes in the HBB gene affect body tissue function.

Step: one, two, three, four
Sequence of How Changes in HBB Gene Affect Body Tissue Function
One: blank
Two: blank
Three: blank
Four: blank

Mutation occurs in DNA sequence

Abnormally shaped amino acids form

Mutation occurs during protein folding

Abnormal sequence of amino acids forms

Proteins that form are abnormal in shape and behavior

Cell shape is irregular, resulting in abnormal cell and tissue function

Answer 1

Here's the correct sequence of how changes in the HBB gene affect body tissue function:

Step: one, two, three, four
Sequence of How Changes in HBB Gene Affect Body Tissue Function
One: Mutation occurs in DNA sequence
Two: Abnormal sequence of amino acids forms
Three: Proteins that form are abnormal in shape and behavior
Four: Cell shape is irregular, resulting in abnormal cell and tissue function