Question

Which type of mutation causes cystic fibrosis?

insertion
insertion

deletion
deletion

substitution
substitution

silent

Answer 1

Cystic fibrosis is primarily caused by a deletion mutation. Specifically, the most common mutation associated with cystic fibrosis is the deletion of three nucleotides in the CFTR gene, which results in the loss of the amino acid phenylalanine at position 508 (F508del). This type of mutation disrupts the function of the CFTR protein, leading to the symptoms associated with cystic fibrosis.