To simplify the expression \(3\sqrt{16} + 4\sqrt{6}\), we first evaluate \(\sqrt{16}\):
\[ \sqrt{16} = 4 \]
Substituting this back into the expression gives:
\[ 3\sqrt{16} = 3 \times 4 = 12 \]
Now, substitute this into the original expression:
\[ 3\sqrt{16} + 4\sqrt{6} = 12 + 4\sqrt{6} \]
Thus, the final result is:
\[ 12 + 4\sqrt{6} \]