The correct response regarding why the equation "CH4 + 2O2 → CO2 + H2O" is not balanced would be:
"There are more oxygens on the left side than the right side."
Explanation: On the left side, there are 4 oxygen atoms from 2O2 (2 x 2 = 4). On the right side, there are a total of 3 oxygen atoms (2 from CO2 and 1 from H2O). Therefore, the equation does not have the same number of oxygen atoms on both sides, indicating that it is not balanced.