To set up the system of equations, we can establish two equations based on the information provided.
1. The first equation is based on the total number of pens and markers:
\[
p + m = 19
\]
2. The second equation is based on the total cost of the pens and markers:
\[
0.25p + 0.75m = 11.50
\]
So, the complete system of equations is:
\[
\begin{align*}
1. & \quad p + m = 19 \\
2. & \quad 0.25p + 0.75m = 11.50
\end{align*}
\]