Question
To develop a PROTAC molecule, the ligand of the protein of interest moiety should have .....
A potency of inhibition higher than 1 uM.
A potency of inhibition lower than 1 uM.
An affinity towards the protein higher than 1 uM.
An affinity towards the protein lower than 1 uM.
A potency of inhibition higher than 1 uM.
A potency of inhibition lower than 1 uM.
An affinity towards the protein higher than 1 uM.
An affinity towards the protein lower than 1 uM.
Answers
GPT-4o mini
To develop a PROTAC (Proteolysis Targeting Chimera) molecule, the ligand of the protein of interest moiety should have **an affinity towards the protein lower than 1 µM**.
This is because a higher affinity (lower Kd, typically under 1 µM) makes it more effective for the PROTAC to recruit the E3 ligase and facilitate the ubiquitination and subsequent degradation of the target protein. A lower binding affinity may not effectively promote the desired proteolytic action.
This is because a higher affinity (lower Kd, typically under 1 µM) makes it more effective for the PROTAC to recruit the E3 ligase and facilitate the ubiquitination and subsequent degradation of the target protein. A lower binding affinity may not effectively promote the desired proteolytic action.
Related Questions
In the Electrophile-first approach for covalent drug discovery, the starting point for the design of...
A PROTAC molecule is composed by the following moieties.
The ligand of protein of interest, the lin...
Which of the following is true about PROTEIN molecules?
The shape of a protein molecule is imp...
High amounts of protein are found in foods like meat, dairy products, and nuts. A model of a protein...