Question

In the Electrophile-first approach for covalent drug discovery, the starting point for the design of the covalent inhibitor is......
A.
В.
C.
D.
The Protein of interest.
The non-covalent ligand.
The warhead.
All of the above

Answer 1

In the Electrophile-first approach for covalent drug discovery, the starting point for the design of the covalent inhibitor is typically **The warhead**. This approach involves designing a reactive electrophile (warhead) that can form a covalent bond with a specific nucleophilic site on the target protein, thus providing a mechanism for selectivity and activity.

So, the answer is:
**C. The warhead.**