Events that are either dependent on sgRNA or independent of it can influence the overall genomic stability in edited cells. For example, sgRNA-independent irregularities, like the introduction of Cas9-sgRNA complexes, can arise from various stresses elicited under different experimental conditions.
paraphrase:
The sgRNA-dependent and -independent events can affect the overall stability of genomes in edited cells. For instance, sgRNA-independent abnormalities, such as transduction of Cas9-sgRNA complexes, can be induced by different kinds of stresses generated in different experimental conditions
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