paraphrase in simple english

Question

The sgRNA-dependent and -independent events can affect the overall stability of genomes in edited cells. For instance, sgRNA-independent abnormalities, such as transduction of Cas9-sgRNA complexes, can be induced by different kinds of stresses generated in different experimental conditions

Answer 1

Both sgRNA-dependent and sgRNA-independent events can impact how stable the genomes are in cells that have been edited. For example, problems that happen without sgRNA, like the transfer of Cas9-sgRNA complexes, can occur due to various stresses created in different experimental settings.