The most accurate response to evaluate the impact of colonial leadership on Spanish settlement in South Carolina, based on the given passage, is:
"Efforts to exploit local Indigenous peoples created long-term problems between Spanish settlers and Indigenous Americans."
This response highlights the negative consequences of the tribute system imposed by colonial leadership, which not only aimed to enrich the acting governor but ultimately led to tensions and conflicts between the Spanish settlers and the Indigenous populations. Such exploitation often resulted in resistance from the Indigenous tribes, undermining the stability and success of Spanish settlement in the region.