The most accurate response to evaluate the impact of colonial leadership on Spanish settlement in South Carolina, considering the context of Don Diego de Valasco's tribute system and its implications, is:
Efforts to exploit local Indigenous peoples created long-term problems between Spanish settlers and Indigenous Americans.
This response highlights the negative consequences of the tribute system implemented by the colonial leadership, pointing out how the exploitation of Indigenous peoples could lead to discontent, resistance, and long-term tensions that might undermine the stability and sustainability of Spanish settlements in the region. While there may have been short-term gains for the settlers through resources obtained via tributes, the underlying issues often resulted in conflict and instability over time.